the important next step is to go through the genomic regions

the important next step is to go through the genomic regions

Aiming to end endo

canada goose store Endometriosis is strongly influenced by genetic factors, so women with a family history are more likely to develop it. 50 per cent of the risk factors are genetic. 50 per cent of the risk factors are environmental. The canada goose uk shop average delay in diagnosis is around canada goose clearance sale eight years from when symptoms start. To effectively diagnose the disease, canadian goose jacket women need to go through an invasive surgical procedure where tissue is extracted to be examined under a microscope. canada goose store

Current treatment is only effective for some. The disease presents differently in different people.

canada goose coats With a background in reproductive biology and gene mapping, Montgomery the project, which he now leads. genetic contribution to complex diseases is uk canada goose outlet made up of lots of genes of small effect. It is not canada goose factory sale one gene mutation that canada goose outlet causes the disease, but multiple genetic variants that contribute to incrementally increasing risk, he says. along the continuum of genetic and environmental risk factors, you cross a threshold where the disease develops. some women have very mild cheap Canada Goose disease, while others have quite severe disease, and treatment is effective canada goose coats

canada goose deals for some but not others. “So, we want to understand: across the spectrum canada goose uk outlet of canada goose uk black friday the disease, is it a continuum with the same risk factors or are there different types of disease? Uncovering how each of those factors contribute to disease will open the door to more effective prevention, diagnosis and targeted treatment, but Canada Goose online it is a slow process. canada goose deals

Canada Goose Jackets these regions is the first step in a process. Genetic markers tell us which genomic regions we need to look at, but in each of those regions a number of genes could be the culprits buy canada goose jacket (or targets). the important next step is to go through the genomic regions to uncover which genes canada goose in each area are canada goose coats influencing risk and how. A recent international study the largest ever completed with canada goose store 200,000 participants worldwide and led by Professor Montgomery research team confirmed nine previous results and uncovered five new regions. study follows similar smaller studies of European and Japanese women. Professor Montgomery research team has also recently published an example of taking one of those regions and uncovering what the likely targets are. at an exciting stage. We have a number of regions to Canada Goose Outlet work on and we know how to go about identifying gene targets. Hopefully it will also redirect the research being done in other labs in this area.” Canada Goose Jackets

canada goose black friday sale It a vital piece of the puzzle because, while you can change genetic factors, it may be possible to influence Canada Goose Coats On Sale environmental factors. Researchers need to find better methods to shine a light on the offending environmentalenvironmental factors are really hard to study because we don know what they are or when the environmental triggers occurred. We may have to track women from conception to understand any input that might be a factor, Professor Montgomery says. But Professor Montgomery may have canada goose black friday sale a solution. believe there is potential to use genomics to identify the environmental factors. Our interaction with environmental factors can leave information in our DNA. environmental factors will leave signatures (epigenetic signals) on the DNA. So, the information may be there. If it is, we can work backwards finding the signatures and then designing experiments to determine what canada goose black friday sale

buy canada goose jacket cheap caused them. not going to be easy and, like genetic approaches, there are no shortcuts. buy canada goose jacket cheap

Canada Goose Parka “We are working with several international groups to analyse epigenetic signals in women with endometriosis to look for signatures of the environmental factors contributing to the disease.” Canada Goose Parka

buy canada goose jacket Professor Montgomery journey so far: buy canada goose jacket

canada goose clearance sale 1989: Professor Montgomery co founds the New Zealand Sheep Genomics Program at the University of Otago to work on genome mapping methods for farm animals canada goose clearance sale

canada goose 1999: He joins the Queensland Institute of Medical Research in a genome mapping program for human complex disease canada goose

2002: He publishes a joint article in Fertility Canada Goose Online and Sterility,

canadian goose jacket international endogene study: a collection of families for genetic research in endometriosis canadian goose jacket

Canada Goose online 2008: He presents a paper at the 10th World Congress on Endometriosis on genetic variation and endometriosis risk, and publishes a joint paper in Human Reproduction Update, Canada Goose online

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Canada Goose Outlet 2012: Professor Montgomery receives an NHMRC grant for defining mechanisms for novel risk loci in endometriosis and is elected Fellow of the Society for Reproductive Biology; he publishes a joint paper in Nature Canada Goose Jackets Genetics,2015: He is elected Fellow of the Australian buy canada goose jacket cheap Academy of Health and Medical Sciences Canada Goose Outlet

cheap Canada Goose 2016: He is awarded Honorary Fellowship of the Royal Society of New Zealand, receives an NHMRC Fellowship, and moves to a joint position at The University of Queensland (IMB and QBI) to focus his research on the discovery cheap Canada Goose

canada goose coats on sale of critical genes and pathways increasing risk for common diseases, especially endometriosis canada goose coats on sale

Canada Goose sale 2017: Professor Montgomery article identifying five new gene regions linked to the Canada Goose sale disease (that he and eight international colleagues discovered) is published in Canada Goose sale.

Yazar: Admin

Yayınlanma Tarihi: 23 Ekim 2013

Kategori: Genel

Görüntüleme: 87 Defa


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